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I wouldn't disagree with the guide - before you get 171, then Infinity/passive is the most effective. Its also possible theres a challenge or 2 that you could complete, even if it meant a bit of a grind.
At this point you want to be swapping between Time/Idle for long runs and Antimatter/Active when you can pay attention to it - remembering to do 10 quick runs to charge up 121 before you start, and manually buying Rep Galaxies, and then swapping Antimatter branch for Time when you can backfill everything.