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Proliferating the science cube that is being consumed for research gives you more hashes per cube; so completing a given research you'll need to consume fewer cubes than the technology tree lists and your research goes faster that with non-proliferated cubes. win-win
And once you're on to white cube science you'll want to proliferate the antimatter and colored cubes used to manufacture the white cubes; and then proliferate the white cubes that will be consumed for research.
I thought they only increased the hash rate, not the quantity of cubes required. So research goes faster, but still uses the same number of cubes. I could be wrong, gonna have to look again.
Methodology:
1. Identified a research that called for 500,000 white cubes.
2. Built a storage array of enough large storage to hold exactly 500,000 cubes (41 3/4 large boxes); then filled it with said cubes.
3.Turned off all white cube usage and allowed all research matrix labs and their feed belts and sorters to run to empty.
4. Canceled the existing research queue and queued up just the 500,000 cube research.
5. Hooked up the storage array, through a spray coater using proliferator Mk.3 to the research matrix labs.
6. Allowed that 1 research to run to completion
7. Removed all the sorters that had been emptying out the storage, emptied all the belts, sorters, and research matrix labs.
8. Put those white cubes back into the storage matrix.
9. Looked at how many cubes were left.
There were 8 boxes entirely full (12,000 * 8 = 96,000 cubes) plus 1 full row (2000 cubes) plus 1 row of 9 full stacks and 1 partial 107 cube stack; for a total of 99,907 cubes remaining.
That means that the 500,000 cube research actually consumed only 400,093 cubes. 400,093/500,000 = 80.02% (Or a 19.98% savings)
The devs have done a pretty job in-game and with tooltips to describe exactly which items can benefit from Proliferator and not and also how. Bonues shown in blue are 'production' bonues, bonues in Orange are 'speed' bonues. Labs will show a blue bonus when properly utilizing Proliferators - which indicates a production bonus and not a speed one.