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For whites, you want to prioritize crowbars and mochas. Maybe few back-up magazines depending on the character. Crowbars especially are really important due to Spirit, since you do not want enemies closing the gap at Mach 10 after getting shot.
As for greens, get a few Guardian Hearts ASAP. Getting one tapped by Spite bombs or Overloading enemies is the most common cause of death. After you've got enough of a buffer you can lean into Clovers, Feathers, Jetpacks, Guitars, Missiles, et cetera. Make sure to get a Cape for good measure as well.
I've only gotten 2 red drops on my run, but I took Dio's and Dagger. Hard to go wrong with either of those. Never had to use the Dio's but it was good insurance.
Once you've got enough items you can basically breeze through the rest of the game.
I could bump the damage handicap, but I feel playing on drizzle just to get the unlock is handicap enough. If worse comes to worse I suppose though.