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There are some things that are only obtainable via godshops, guild shops etc.
There are numerous "backer trait" materials that are only found as loot rewards, but generally speaking you're going to find loads of these things over time (especially if you play on realm intensity 5).
Trait materials might seem rare because there are a ton of them but you'll passively acquire more than you'll ever use as you get further into the game.
As for actual rare things, there's Nether Stones as you said, Jewels of Zantai, Sigils of the (race), mana for most of the Dumpling race, and drops from the Pandemonium King/Queen. That's pretty much it. Everything else is eventually either easy to farm or can't be gotten rid of.