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Mikoi is an EXTREMELY strong character as her charged resonance blast debuffs all enemies on screen with resonance, which will allow you to wipe out all mobs on screen if you can follow it up. It can also be used against bosses, effectively multiplying your damage output by the number of body parts they have - 6 or 7 for the tentacles, 3 for the crab, 2-5 for the hoarfrost duo. Ineffective against the last boss because he doesn't have any extra body parts.
Non-DLC I recommend Cluck as he's buffed by egg-related items and artifacts; Quill will allow you to scale up your damage extremely quickly; Lotte for the reasons FENTON described; Gill for harpoon builds and Krillstoph for faster, stronger melee.
Shelbie's character trinket will be in use practically all the time but IMHO it's not very fun and the Deep Sea Duo DLC I confess I haven't found much use at all for.