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From my experience it doesn't interfere with lifesteal but significantly reduces any other source of health regen like the regrowth trait and tranquil heart .
But if You have it on You really don't need any other sources of healing tho !
I don't even spend any trait points on Lifesteal or Leech but this ring alone combined with that legendary perk has better survivability and health regen compared to those traits and relics , it only takes one ring slot , You could swap Your relic for something like the Void heart as well
If You're using it without the legendary perk it's more situational , You have to be at light or medium weight class to be able to dodge perfectly and even then when You got hit and need the healing You better pray it didn't stagger You or pushed to ground ; Kind of makes it useless
With the perk tho it's a different senario You can be tanky , take most of hits to the face then refill your health with a backdash
Thats what I thought too cause there are lifesteal traits so it would not make much sense if it benefited from both.
Also I do not have hard proof but it looks like healing effectiveness does not affect burden of audacious heal.
During some testing I ran into some real odd discovery. I tried to do face tank build with crisis core and perfect dodge rings. Had leto mark 1 on me and it just would not cut it on apocalypse. For one the damage taken that triggers crisis core has to be to hp and not shield, so warden was not really a good option for what I wanted to do. Idk how do people made it work in those vid where they take no dmg at all, my build really only lacked tranquil heart but I really did not allow me to face tank everything.
Whats even stranger is that once I swapped back to my usual radiant armor set, which has like 30+ less armor or so, I somehow took less damage from same mobs than I did wearing full leto 1 set. That I really can't even explain, all I did is armor swap, rings stayed the same.
Leto MK2 with Strong back & Fortify would be enough DR to get You through out most senarios at apocalypse
Invader's skill is also a good idea if you don't want to use the legendary
It goes hand in hand with chef amulet and redeemer side arm , it basically gives you infinite amount of relic charges with all the archetype relic buffs