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The "endgame grind" is getting mythic fragments for your relic, but you can only get those when you have all 10 archtypes leveled to 10. So you need to be working on that throughout your playthroughs, and the best way to do that is in Veteran.
The only thing nightmare offers over survivor is the end rewards for beating the game, which are account bound.
The basic difference is that rerolling your Campaign will reroll the whole game vs Adventure just rerolling a specific area. I don't think there's much difference besides the fact that some areas are not eligible for Adventure Mode (please correct me if I'm wrong).
There are only a few reasons to redo a campaign:
1. You missed an item that can only be received during campaign (ie Labyrith and Root Earth items, Nightweaver's Web cross-world items, etc). These cannot be re-rolled in Adventure.
2. To receive the rewards for beating the campaign at a higher difficulty.
3. If you're at a point in you Adventure that you want to stop and wait for a friend to jump in and get the loot you're about to get, but you want to keep playing on your own - so you start a new campaign.
Other than these, there's no reason to redo campaign. Just run Adventures on Veteran.