Best runes to pick next...

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I currently have 5/5 for lifesteal, soulsteal, might, lucky roller, reinforced, folded, retaliation, stone.Also 2 bounty, 2 resolve, 1 siphon, and 1 vault.
Once my armours are all unlocked i will drop the stone runes, but that won't be for a while. Once i max out my final few rune capacity upgrades i will have 180 capacity to work with. I also haven't hit charon's first cap yet, so i can probably squeeze another rune or two out of him.
Besides what i'm already using, what else is good? i figure more siphon could be good if i start using spells more in combat. Idk if lucky roller is a waste or not. Am i better off with sharpened runes to increase base crit chance for non skill crit attacks?
Is amplification rune worth using? Does status stack? i.e if i increase duration can i get a higher stack of DoT?

[Omegatherion]

How can you play the game with only one vault rune? I have 5 of those and i wouldn't want to go without them.

Other than that, if you buy more rune upgrades in the soul shop you will face the problem from the other direction: You won't have enough rune capacity for everything you want to equip.

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Originally posted by Omegatherion:

How can you play the game with only one vault rune? :lunar2019grinningpig: I have 5 of those and i wouldn't want to go without them.

Other than that, if you buy more rune upgrades in the soul shop you will face the problem from the other direction: You won't have enough rune capacity for everything you want to equip.

I've never felt like i needed more, and the minor utility of any more would be a waste compared to benefits from other runes.
You've misunderstood my problem; I have bought all soul shop upgrades, and have almost maxed out my rune cap. I have enough red aether to buy every rune upgrade. The ones i listed are those that i have equipped. I'm wondering what i should prioritise with my last bit of rune capacity.

[Gnodab]

Amp runes are good. 6 is the sweet spot for extending the duration on Chef's Burn so you get an extra Skill Crit. They're also generally good for Mage and Boxer to keep up Mana Leech and Combo. Debuffs themselves don't stack unless they say so, like Poison.

Take at least 1 Siphon Rune if you're playing Gunslinger or Boxer, as just 1 kicks you into 4 mana per hit from 3. If you're using 50 Unity Leviathan, use 2 so you go from 4 to 5.

Other than that just build according to your class' strengths.

[Rhadamante]

DoT + Amp runes only extends the duration so they may add additional ticks of damage.
I say "may" because sometimes they don't. Ticks happen every 0.5 sec so if one amp runes don't add enough to reach that, it won't add a tick. Don't have the right numbers so you'd need to experiment (or wait until I check this myself as I need to at some point).

Vault/Dash/Haste runes are up to preferences, so no advice, add as you need.
I'd drop the bounty, +20% gold where you're at (you seem to be far enough in the game as to have 5 runes)) isn't worth the 80 rune weight you're using. Put it into more ore or something else.
I run 5 Resolve but that's like Vault/Dash/Haste, it's up to preferences so see if you ever feel like you needed more resolve or if you're fine.
You might want to add a few sharpened runes, either for the crit chance if you don't skill crit often, or for the super crit chance if you do.
Add some High stakes ! No sense in increasing super crit chance if you also don't increase the super crit multiplier for its damage. They're also great if you find Obelisks, as they make that relic a lot better.
Check to see if you ever lose lots of armor during a run and if you do, add some Quenching runes (they're also useful as healing but only if you really need it)
I don't know if you use Magic Damage a lot (spells, talents, relics) but if you do, the Eldar/Focal runes could be of some use.