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An easy way to see if it's permanent or temporary is how easy/hard it is to get an amount that gives you a real boost.
For blood magic spells, any spell with a cooldown gives permanent stuff, the rest are until rebirth.
Iron pill gives you a pitifully low amount per cast compared to what your equipments can give you, on top of having a long cooldown between casts.
Augments, time machine, wandoos and advanced training are examples of things that reset on rebirth.
On the other hand, iron pill, NGU, itopod and most of the stuff unlocked later are permanent (or at least have a permanent aspect to them).
Iron pill is still cheaper than spending EXP for it so, Ill just focus more on iron pill for those changes I want. Im at 1.2m blood per completion and, can get meaningful stats when I want to save (like before bed) so, probably will save me alot of EXP in the long run of things. :D
https://steamcommunity.com/sharedfiles/filedetails/?id=2636255906
Clearly says Iron Pill is "a small permanent boost"
That's also where the (fairly rare) adventure stats from other sources that are not equipments or bonuses end up being added to.
(You will later. much much later. but not now. for now just forget that it's a thing you can do)
Ive tried to use that thing multiple times. Alas.