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http://www.virusradar.com/en/update_info/7462
:(
Send the File to ESET and said it is part of the Game, hope they look into it ...
EDIT: I turned off NOD32 and launched the game and it works, strangely I had lost 6 secrets, but luckily I had made a copy of my seria.txt and so.sol file before I did anything and so I got back my most recent save. Now this might not have anything to with this NOD32 thing, I did run CCleaner earlier today and I hear that can mess your saves up in this game too. But if you wanna be sure, just google Binding of Isaac Locate Save File and save the files necessary to make sure you don't lose any data