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Thanks a lot for that! I had problem with the resolution for about 6 mouths! This solution solves the problem, thanks for the help :D
Thank you so much. Been looking all over for how to fix this. You are a legend!
I doubt they changed how the game files are installed on your PC for this game though, so you may want to check if your game is correctly installed.
In your library, right-click BOI and go to "Properties", then "Local Files" and "Check Integrity of Game Files"
I found that sometimes if you have amd graphics, it likes to default optimize games. When I disabled amd freesync for binding of isaac it worked perfectly, no fullscreen game crashes