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I also think it might be easier if you try to get 1 achievement in 1 run, not all of them in the same run. For example this will allow you to take Spirit of the night when finishing an early set of floors and give you a lot chances to finish the next set without taking damage.
And from my experience the dark boy (or whatever achievement is for finishing the depths without taking damage) is the hardest.
Good luck!
- no way to take deals with the devil
- can't use the blood bank
- can't use polaroid invincibility
- no curse rooms
You might be able to make it with Dr. Fetus or Epic Fetus but after a while those get really boring.
I think, no damage run is best with Judas, because of biggest damage output and decent speed. You should consider starting on Large Marge challenge (XL floors) or Isaac Was Good Today (it gives you more damage, speed and also ability to fly).
P.S. You can start a challenge with any character if you are fast enough,