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Anyway..
I rather like Eve, she is the only one I really get anywhere with, not sure why?
Isaac with D6
Demi-god tier:
Cain
Judas
Good Tier:
Isaac (no D6)
Maggy
???
Bad Tier:
Eve
Terrible Tier:
Samson
That's just for me personally but knowing the true power of the D6, I simply can't put Cain above it. If you don't know the power of the D6, go watch a Cobaltstreak isaac run where he can force the game to give him every item he wants by abusing it.
Samson is the worst, his only benefit is Bloody Lust which is actually a terrible item anyway.
And thats pretty awesome. I suck at playing as Eve :L
She just doesn't have good damage and ♥♥♥♥♥ of Babylon gives her about Cains base damage.
And I just saw that it should be WOTL
I'm such a nub sometimes :L
Isaac is barely below Cain in my opinion, I just think the D6 has little value in the Womb/Utero and the Catherdral. If you do save it for the chest, it does have amazing use. (But I like having a good spacebar item for the Isaac fight personally)