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And if you're lucky enough to get Polyphemus with it, you'll just oneshot bosses :)
EDIT : answered to a necro'ed thread, dammit u_u
Don't use Wiki it's horrible most of the best isaac players will teill you to stay away from it.
Use this site. http://platinumgod.co.uk/
Some items to avoid : Lump of Coal, Brimstone, IPECAC, Technology 1/2, Inner Eye/Mutant Spider, Tough Love, Loki's Horns, Mom's Eye, Chocolate Milk...
Great items to pick : Any damage/tears/range ups ( specially Polyphemus ), The Virus, My Little Unicorn/Book of Shadows, Wiggle Worm, damaging orbitals ( Guardian Angel, Sacrificial Dagger, Cube of Meat ) etc.
Yes, that's why I'm saying to avoid them. If you have the D6 you could reroll these instead of picking one up, get nothing from it and in some cases decrease your chances to get a special item.
wiki is usually wrong :L
There are 6 (passive) items I never take:
• Mom's knife
• Wiggle worm
• Chocolate milk
• My reflection
• Number 1
• Ipececac