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You can guarentee yourself a first devil room on the second level and onwards if you do not take any red heart damage on the floor. Note: You need to restart your game to reset the devil deal chances.
Check out the wiki page. There are alot of strategy for each characters.
How did you enter the Dr Fetus challenge as them? From what I understand, you can only play as Isaac in the challenges. I still have to beat Mom's Heart 4 or 5 more times to unlock the content past that. Maybe I should hold off on these characters until I unlock more and can get further achievements in a run with them. They aren't ones I would use normally and I don't plan to play them much outside of getting achievements associated with them.
you CAN only play as Isaac during the challenges. Best thing to do is to dodge/learn how to dodge to best defend against the low life. Also, pick up soul hearts at the end of the level so as to best give yourself a fighting chance!