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Gold key rooms are generally meant to be impossible, since the loot there is insane, so as you pointed out, you'd generally only go in there if you have obscenely good equipment/stats.
Starting club is probably the worst melee weapon in the game by far, because of it's trash scaling, if you need knockback, going maces is generally better since they can be used with heavy hits for double damage and even more increased knockback. Though, starting with mace requires turning on advanced player mode in the options
Labs themselves are meant to be the hardest content in the game, so I'm more or less fine where they stand. Quooz merchant was only added as part of the recent update more as a response to players generally having a lot of cash, not because of labs specifically, but they work pretty well together you are right :)
Thanks for the feedback!