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If you knock her out (activate non lethal attacks under your Passive skills), he will kidnap her.
If you follow your urge and you kill her, or threaten to kill her then Marcus will become hostile, yes. Moonrise Towers will not become hostile, though, but if you kill Isobel, the Ketheric arc changes somewhat.
However, bear in mind that if you do not kill Isobel, the evil dark urge story arc has some pretty nasty surprise for you later on.
Not much of a surprise. The only way the Durge arc hasnt a nasty end is if you follow the redemption path.