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Gale can be killed upon first meeting if you're the Dark urge - bye bye arm, and he falls into the portal never to be seen again. I assume he blows up wherever that portal leads.
Get outta here, you can interact with the Kua-Toa?!? I had no idea! Only found the cove in my second playthrough.
Halsin can be 'forgotten' if you let the shadows destroy the shadowfel portal.
Laezel will momentarilly leave party when you approach the northern pass to approach the gith. If you dont follow her, she will be offed by Voss.
Also not forget sacrificing a character of choice to Booaal. the remainders in the party gets a buff that lasts to their next death and the kuo toa is left unmollested to chant, gives advantage on attack rolls against bleeding targets.
The Slayer Form has a bleeder move.
I never stake Astarion as he can get a potion with permanent +2 strenght in act2 with a quick visit to moonrise and talking with the bloodmage drow that anyone can use. Reputedly you can lose Astarion in Baldurs Gate if you let the invading spawn kidnap him.
Kill the Grove: Lose Wyll and Karlach. Lose Halsin, gain Minthara. You can also lose Gale here if you don't drive him off earlier. They all don't actually die, but I think Wyll & Karlach turn into Illithids?
Stake Asterion.
Let Shadowheart kill Lae'zel in camp (or side with Lae'zel and kill Shadowheart).
Sacrifice Shadowheart (or Lae'zel) to BOOAL.
You can just leave Minthara to her fate in Act 2, but if not you can drive off Shadowheart in Act 2 and sacrifice Minthara to BOOAL instead. You can also lose Halsin if you just ignore the Grove/Tieflings and move onto Act 2; if you save him he comes along for the Act 2 plot but won't join you after.
Karlach will get pissed off and fight you if you kill everyone at the grove before finding her. I think that may be the only way to get rid of her
Shadowheart will fight you during the Night Song scene in Act 2 if you fail your rolls
Chaotic Evil run can easily leave you with less than 3 companions if you just be a ♥♥♥♥. Literally had trouble keeping a full party when I tried it
Refuse to feed Gale and he blows up and kills everyone. I want to live, yo! Also, I don't want to "lose" characters, I want them to die by my plot choices, directly. Giving Asterion to his daddy to sacrifice is more along the lines of what I'm looking for, not having someone wander away from camp just because my cooking sucks.
Gale leaves and blows up on his own if he likes you enough. The rest turn into Mindflayers, IIRC. There aren't as many plot methods to straight up kill them as there are to just get them to ♥♥♥♥ off and die off screen. Even still, you can often force them to attack you for doing stuff they are diametrically opposed to and just kill them that way, which is probably the closest you'll get for Karlach.