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Killed him in one hit that way on my current honour run.
Also, if you want to go to all that trouble, you could persuade him to give you the bell to call Flesh. Then, go elsewhere, start a fight, call Flesh and "accidentally" kill it. After this, go back to the lab and fight Balthazar. Silence him, if possible, because he loves to use Cloudkill.
I think you should be able to either pickpocket or buy his Speed Potion from him so he won't get an additional action.
This should be enough to make him pretty easy to kill.
By that point you should be at a high enough level to wipe him out without too much trouble provided you have a couple of burst killers like fighter+paladins and your party has 5+ initiative apiece so that you can dump on B and finish him in the first round, followed by mopping up the others.
You want to slay? Juice 2x Barbarians on Elixirs of Cloud Giant Strength.