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The thing is: If you read the fine print of almost all RPG systems, you might know that they have a kind of "DM do whatever they want clause". All that "the priority is fun", and "your story your rules" and all the "good stuff" northfolk like.
So yeah, there are a lot of DMs who accept things to make the game "more fun", which to some mean "easier".
But let's assume we are talking about 5e, basic version, no house rules, etc.
In which case vampires are treated as just some undead.
In which case you can kill them, like burning them, and then revive them. And once they are revived they will come back alive, not as an undead, aka being "cured".
And I can not find anything supporting your claims that there are any other overgods besides Ao. Only speculations and assumptions that some could be overgods but often times their power level is way inferior or their might is concentrated on a small aspect like it's the case for Io.
Yes. It is technically a magical disease, I believe, same as mummy rot or the like which can only be cured by magic, never by conventional recovery (like say the flu). But its worse than that because magical cures usually do not work on it due to its incredible power/level of difficulty. Its meant to be a big deal to get rid of it, and its meant to be highly risky (and rewarding, of course) to bring down even a lower level vampire. A master one is as epic as slaying a dragon, really, due to the risks caused not just by the master but his lackeys which include lesser vampires, spawns, and greater undead like wights/wraiths etc which are all nasty as well.
Tbh I find it more fun when a DM is more punishing when players wanting things that a bit out there. The entire consequence of actions....