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I wouldn't say the Vampire Knives are garbage Post-Plantera, personally. They don't really put out as much in damage, but I they make for a quick way to heal back up to full health should your potions be on cooldown. At my point in endgame, I find myself using the Flairon, North Pole and other weapons normally, but then I swap out to the Knives if I get below ~350 HP. They trade off damage for what they boast in health restoration. o:
That obnoxious paragraph aside, I'd say the best weapon depends nearly entirely on your playstyle (Melee, Ranged, Magic, Summoning). Melee weapons come from the Corruption/Crimson chest, Ranged weapon comes from Jungle, Magic weapon from Hallow and Summoner weapon from Frozen chest.
Don't be shy to open all of them should you get each of the molds, though.