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add friend me then. don't need loot btw)
Unicorn mount and a large perpared arena (with dryad in the center, healer by bed below) can make the fight easier since you can benefit from the defense boost and lead the boss away before recalling to nurse to heal.
Of the three, Skeletron prime can be the easiest since you mostly just have to avoid the hands. Defeating Skeletron prime can also open up some new weapons and equipment to kill the twins. For the destroyer, the harp is usually suggested.