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8 defense potion
Well Fed buff + 2 defense
accessories with +4 defense each
2 defense from Obsidian shield
1 defense from Cobalt shield
1 defense from Obsidian skull
1 defense from Shakle.
Full Molten Armor +25
Obsidian Shield +6
Cobalt Shield +5
Shield of Cthulhu +6
Obsidian Skull +5
Shackle +5
All warding + ironskin potion + the dryads blessing (which gives 8def) + well fed
So 70 defense in expert mode and 68 in normal mode without shield of cthulhu
And here's why...
(Gear - All Warding +56)
Molten Armor + 25
Shield of Cthulhu +6
Obsidian Shield +6
Cobalt Shield +5
Obsidian Skull +5
Shackle +5
Any Accessory +4 (Full Tank - Worm Scarf)
(Buffs +25)
Ironskin +8
Dryad's Blessing +8
Bast Statue +5
Exquisitely stuffed +4
(Difficulty)
Master: 81 Defense
Expert: 77 Defense
Classic: 75 Defense
If you want to be even tankier, I would recommend Endurance and Lifeforce potions (though you can only obtain Lifeforce from Shadow Chests or Gold Chests within 250 blocks of the bottom of the Underworld in Pre-Hardmode.)
Oh, and since I'm here, the max defense in the entire game is 208.