If you google "Breezehome multiple adoptions" there's a version of the Breezehome TNF mod. Never used it so IDK if it works or not, there may be other alternatives, alternatively there are lots of nice house mods that work well with Multiple Adoptions.

Not to mention the Hearthfire Multiple Adoptions mod page has a couple of dozen suggested house mods, including a few which appear to be Breezehome remodels.

Okay thank @gnewna.