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I really like Eve also. I'd call her 3rd best. ♥♥♥♥♥ of Babylon is a really good item, and devil room items can get you 100% demon form. (especially if you get Guppy's Paw, game over, you win).
I know that it's not technically invincible, but it makes the first few floors less of a grind if you get Habit early on. The best advantage is being able to take everything from all curse and trap rooms without care and make more deals with the Devil than other characters. Not only that, you can really abuse the blood bank. With the Habit on the first floor with Maggy, you are guaranteed a win. With battery or 9-volt, you are almost guaranteed the win.
Even without a spacebar charge item, you should be able to get past the first 2 floors without getting hit and only taking damage from the curse rooms. By then, you would probably have picked up a speed upgrade. But without the spacebar charge items, I'd put Isaac 1st, since the start bomb and D6 are very useful.
1. Maggy with Habit, Battery, or 9-volt == winning while playing stupidly.
2. Isaac-- D6 to get a whole bunch of good passives early on, then get rid of it if you find a really good spacebar item after beating Mom.
3. Maggy without good luck
4. Cain-- weaker than other characters when you get technology 2 or chemical peel. I just basically use him as Isaac starting with 1 heart and bomb traded for PHD and a tiny bit of starting damage.
5. Eve-- can abuse dead bird and ♥♥♥♥♥ of Babylon while essentially getting a free curse room on the first 2 floors. Sucks when you accidentally make a bad move on the 2nd boss when you don't have spirit hearts.
6. Judas-- Starting with Belial is nice, but I just don't really use it, so to me he's just Cain with worse luck and less health.
7. Blue baby-- unplayable if you don't come across spirit hearts. Only the nail makes him close to playable. Most of the time, he just feels like Isaac without D6 and a huge health disadvantage.