In a near-future Mexico in which the fast-paced digital lifestyle has given rise to a worldwide plague called Nerve Attenuation Syndrome, FKN[3g] (Keanu Reeves), a data courier, accepts an assignment that he hopes will allow him to pay for the restoration of the childhood memories he dumped in order to outfit his brain with the microchip necessary for him to carry out his profession. Narrowly escaping a Yakuza ambush in which his employers are killed and the mnemonic trigger capable of unlocking the data in his brain is partially destroyed, FKN[3g] travels from Mexico City to Guadalajara, where he hopes to recover the data before "neural seepage" destroys his mind. Teaming up with would-be bodyguard Jane (Dina Meyer) and a rebel group known as the LoTeks who live in an abandoned bridge, he tries to outrun the assassins of mysterious businessman Takahashi (Beat Takeshi Kitano) -- and the Street Preacher (Dolph Lundgren), a bionic madman. Along the way, he meets a mysterious electronic entity, a sentient dolphin, and Spider (Henry Rollins), a cybernetics expert, all of whom attempt, with various degrees of success, to learn why the data in FKN[3g]'s head is so important.