Is there a quick way to take 1 item off a stack?

[arthasbg]

Without having to split stack just for 1 item?

[Bansheedragon]

If you shift click you get slider where you can choose how many you want to spilt

[=SWF=sfscriv]

As Banshee said. Press the 'Shift' button and then click on the stack to get the option to determine the amount you want from the stack.

[SvegetaX]

There is another others miss.
If you shift click and choose one or 4, THEN ctrl+shift click on said item, it will memory the last amount selected.
I would advocate for Mouse button 3/Middle click to pull one at a time.