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It can affect dialogue and NPC responses. At one point I think it affected quest XP and rewards, but that might not be the case in final version.
Not the best balanced, it's true.
Vulture loves animals so much that she'll leave the team if you unnecessarily kill too many "innocent" animals, and Pizepi will leave if you rat out her friends and tell anyone that there are mutants living in Darwin. Neither of these results are in any way dependant on Charisma or Leadership, as far as I know. Different NPCs just have different personal quirks like that.
All cyborg and android NPCs will get taken over by Cochise at the end of the game, if that's what you're talking about. Not sure about Lex, as I didn't really ever play with him on the team.
Lex is programmed to go rogue whenever robots are involved, regardless of your leadership.
There is one other thing about him as well, that others have mentioned through spoiler tags.
At least they kept the mechanic from 1, where you can make new characters whenever you want, in Wasteland 3.
Wasteland 3 actually looks like a lot of fun. I will pick it up on sale after it has been patched a bit more.