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My vote goes to Cursed Eye. It's the only item in the game that has zero synergy and warrants a reset no matter how far you are. Even something like guilliotine you can still try to play, Bob's Brain still has strats to use with it. Only Cursed Eye is all negetive.
Tarus + Book of Shadows = total invincibility for the first 30 seconds or so of every room. It's an amazing synergy.
I love Taurus, especially if I have good speed. Free invincibility+damage for just standing around is great.
The poop. (get maybe 5 cents maximum the whole run, unless you're lucky enough to also get petrified poop)
Butter bean (a knockback that barely pushes ennemy).
And they take the spacebar slot.
Here are my vote for the worst items in the game.
Sure cursed eye downside is really annoying an can ruin the run, but the effect it gives is pretty cool.
Soy Milk has both game ruining synergies and game-making synergies, it's fine.
Same for magnetic tear and the antigrav thing.
screen bean