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A twinstick shooter/roguelike hybrid, The Binding Of Isaac combines a tough but mostly fair difficulty with near-infinite replay value. Each playthrough lasts only an hour or two (assuming you don't die early on), but the procedurally generated levels, enemies, and item spawns make each one unique. The sheer amount of content is also impressive: I've sunk over 115 hours into the game as of this writing, and there's still a good bit more I haven't unlocked or discovered yet.
TBOI has an old school mindset to it, in that there are tons of different enemies and powerups, but the game does not spell out for you the best way to take on the enemies or make use of the powers, or sometimes even what the powers do. This might sound off-putting, but I find it provides for a highly satisfying sensation of skill progression as you work these things out for yourself. Over time, you will even begin making tactical decisions about when to skip a powerup that doesn't work well with your current build.
The Wrath Of The Lamb DLC is also heartily recommended, which provides a huge increase to the number of powerups in the game, a new character to unlock, and an entirely new class of pickup, all of which make for even more build possibilities; special challenges that unlock new powerups upon completion; a plethora of new enemies, bosses, and level permutations; and even a brand new level at the endgame.
In the interest of full disclosure, the game does have a number of bugs and glitches, including a rather annoying bug regarding unlocks that can result in 4 specific ones being removed from your save history, making you have to unlock them all over again. Very few of these bugs are gamebreaking though, and the few that do cause you to have to cancel your current playthrough are extremely rare (I've never encountered one in all my playtime). Reading the wiki page on bugs, and keeping a spare copy of your most recent so.sol file (which records your unlocks and settings), will help you avoid nearly all of them, and those that can't be avoided tend to be completely trivial at worst, so I would strongly advise you to not let these few minor annoyances dissuade you from picking up one of the best values for the money you can possibly find on Steam.
This game is unbelievably difficult and unbelievably addictive.
The lowest level of difficulty in this game is labelled "hard". From there, it progresses to harder, hardest, hardester... Your lives are measured in seconds, and yet it never feels frustrating.
Unlike most games, where gauging how much better you've gotten is an academic thing--comparing your present scores to your past ones or noticing that previously challenging sections are now easy--Super Hexagon makes progress an actual, tangible sensation; I can FEEL my brain deciphering the chaos into coherent patterns, and my fingers begin to react without conscious thought, dodging and weaving my little triangle through the onrushing maze of walls trying to crush me. I think I achieved nirvana at some point.
This game is pure elegance in simplicity.