Bizarre, twisted, and disturbing. The Binding of Isaac is what happens when you cross elements from roguelikes into the dungeon aesthetic of the original Legend of Zelda. As you do various things in the game, you will unlock more and more items that will randomly appear in item rooms.

You will die a lot. You only get one life (unless you get certain items) and you have to start over completely, but the game is built for that sort of thing.

The only problem I have with the game is its performance; it has a tendency to slow down a lot. Apparently it's a problem in its Flash roots.