Just...wow. Its short lenght maybe makes this game not worth 10 bucks, but this is a brilliant little masterpiece that every gamer should buy at half (or less) of its price.

Loosely based on a Biblical story, The Binding of Isaac is an original and flawless mixture between rogue-like and top-down shooter, with a Zelda-esque world design.
Hard as hell, you'll need plenty of luck other than pure skill.
I suggest to trying the demo (wich is on Newgrounds); and yeah, it's a flash game, but being so well-made you can easily forget about that.

Awesome puzzle game, with a great art-style and soundtrack. Concept is cool too, and the game never stops surprising you.