This is a real issue, as this game was one of the ones I was truly looking forward to playing again.
I have the "fist" glitch, which is essentially a bug that causes the cursor to remain in a "combat" state. Also, and I'm not sure if this is part of it, but movement is completely broken. Whenever a location is clicked on the map, Minuteman runs off the screen and never looks back. I'm talking about into the black abyss of "invisible walls".
Searched for fixes, found absolutely nothing that helps. Tried pretty much everything suggested, including "compatibility settings", clicking specific places to start a new game, etc, etc.
Any help/confirmed fixes would be greatly appreciated. I'm running Win 8.1 with a GeForce 760.