Ok so after having finally decided to mod skyrim last month seeing as how the game is officially complete and will not be patched anymore. I found out to my dismay that ENB and Crossfire just don't get along.
There are 2 known fixes to this after having searched for weeks:
1) use either fear.exe or acb?.exe (or something like that) crossfire profile for TESV
2) rename TESV.exe to oblivion.exe and with SKSE installed you have a skse.ini file that points SKSE to oblivion.exe. Fix 2 only works with 5000 series crossfired and back because 5000 series has an oblivion.exe profile. This profile is missing in 6000 series+.
This makes DOF work without blurring screen or white strobe flicker bugs. So whats the problem? You get a YELLOW FLICKER in the main menu, quest log, and local maps. To counter this I installed this mod from the nexus that makes the backgrounds of these menus black. Lame huh?
I was not satisfied with those fixes. So then I started playing around with the hundreds of crossfire profiles and then I remembered that when Guild Wars 2 beta and official release first came out they also had screen flickering. It was fixed for those games. So then I thought meh what do I have to lose? So I set TESV to use GW2*.exe profile and ... SUCCESS_KID.jpg!!!!111!!!
Not only does running Skyrim with GW2*.exe fix the annoying yellow menu screen flicker fear.exe/acb?.exe/oblivion.exe
cause, but ENB works flawlessly, and most importantly the game does not suffer from any FPS drops, in fact I think it runs a little better though that might be a placebo effect. I saw no drop in framerate. Go on ahead, give it a try.
Using RealVision ENB found on skyrim nexusmods
Running AMD catalyst 13.4 WHQL with 13.5 CAP 1 profiles
2 Sapphire Radeon HD 6970s
using GW2*.exe profile is nearly flawless it would seem, and I've been experimenting with other games i know for a fact had flickering issues but were later resolved in later catalyst releases and came up with the following results.
GW2*.exe profile: near flawless with all ENB settings enabled including DoF. Water may flicker.
Crysis 3.exe profile: near flawless but when entering menu or quest journal colors get inverted.
BioShockInfinite.exe profile (for some reason listed as "White List App" in catalyst): flawless for the most part, still testing it.