I thought I would share this with everyone, just in case someone has a similar problem but hasn't identified the cause yet.
I currently have 62 mods installed for my version of the game, so I am always really careful when adding a new one incase it causes a conflict. I have just added Wet & Cold and Real Shelter to my mod list tried to load the game to test them having used BOSS to verifiy the load order.
My game immediately crashed to desktop after the initial Bethesda flash screen.
I tried unflagging both mods on the load list and the game then loaded normally, and by process of elimination I isolated to to Real Shelter. If that mod is in my load list the game crashes.
It may not be the mod itself but a combination of it and another mod I have already installed and tested, but according to the author it should work with Wet & Cold, so that shouldn't be the problem.
Just thought I'd mention it in case it helps someone else track down an issue.