Entire computer crashes trying to run the game.

[Calibrate5400]

For some reason, even though my computer was definitely able to run it in the past, and even though I am not using an ENB and am getting a good framerate, After a few seconds or a few minutes, the entire computer abruptly crashes. Not a bluescreen, not a simple CTD, it literally and abruptly shuts off entirely. I think it has something to do with PerMa (Patchus wont work because it cant find a "Plugins.txt" file), but I am struggling and thus I am looking for an answer here.

Current load order to provide more insight:
Dawnguard
Hearthfire
Dragonborn
SkyUI
Perkus Maximus Master, Warrior, Theif, Wyntermist, Mage
Alternate Actors
Wet and Cold+Ashes and Holiday
Skyrim Unbound
INeed
Rainbows, Shooting Stars, Splash of Rain, Take Notes and Pure Weather

[Garrett Aelito]

Use LOOT to sort your plugins.

But it sounds like your CPU is overheating, or possibly your graphics card is critically overheating and is hard-crashing your PC. Try cleaning out the inside of your computer; all that dust can be really bad for your PC's health.

[Rusty Bucket]

I had the same problem after reaching 300+ hours of play. I tried everything but finally had to lower the graphic settings to medium. That fixed my problem. Good luck.

[SpeedFreak1972]

Sure it isn't driver or hardware related?