My game is pure vanilla with no mods but I have all the DLC. The high-res texture pack makes it so I cannot fast travel more than a few times before it starts caching and stuttering. A simple exit to desktop use to fix this but now it requires a reboot.
How are you guys getting past the absolutely horrific memory management code within Skyrim? This thing must leak thousands of objects every time a grid cell is unloaded in order for it to start stuttering so fast. I suspect high-res textures reveal the core issue sooner since they require more memory.
I am very surprised this was never fixed as it tends to ruin the whole experience.