This game set the archetype for games where the player wandered off in the wrong direction, stumbled upon a random wandering nasty thing, and was instantly atomized when the thing looked at them cross-eyed.
It is brutal and unforgiving compared to most games where a single player character moves off in an epic quest - and never encounters anything that poses too much of a problem.
#1) Always move with the heavy stuff equipped. Your melee and fisty specialists can waste a round switching to fists if it turns out that you encountered Bambi instead of Vanadium Vultures.
#2) Always hide and rest up, even if you are *only* at 90% health - yes, it makes a difference.
#3) Try to wander around and find simple things to do before going into a known encounter.
I'm giving thumbs up because there are a few fun things to do, like the PROTON AXE! But mostly because I played the game long enough to be hypnotized by it. I can't tell you how many times I reloaded saves because I died in the DOS original.