It's a little bit like the Heroes of Might and Magic series, minus the fantasy. The setting is interesting and not often explored in games, so it's nice to see it done justice here. The combat is challenging and fun, and the management aspects will require you to pay attention. Each team member has a story and a personality, some will vehemently disagree with your decisions and others will come to you for advice about their personal problems. Graphically, it looks ok and runs well on older hardware. The soundtrack, although short, is excellent and I often find myself whistling the tunes when I'm not playing the game. You can choose to be a care bear, a ruthless genocidal maniac or something in between. You will often face tough moral questions and your decisions will impact the moral of your followers.
If you are interested in this period of history, or if you like turn-based strategy, or even if you are suffering a bit of genre fatigue and want to try something different then Expeditions: Conquistador is definitely worth a shot.