Gateways refuses to launch on my Parallels 8 VM running Win 7, with Radeon 6750M. It complains that I don't have a "HiDef" XNA profile, which may be beyond Parallels' translation ability. Gateways is the first game that I've encountered to actually not work on this setup, Skyrim runs fine, Alan Wake even drags by at 20 FPS. I never figured on a little 2D romp being incompatible, and am sorry I bought before getting the demo.
Edit - the new build (1.12 Humble) works. Thanks dev!