jamesc70 Feb 1, 2013 @ 12:08pm
Most OP item combo ever - Homing Spectral Big Bomb shots lol
Dr. Fetus - all shots are bombs
Bobby Bomb - homing shots (homing bombs with the above)
Oujia board - all shots are spectral and pass through things like rocks
Mr. Mega - makes all bombs large bombs

Wow was that an easy runthrough, and first time I killed Sheol. Mini bosses went down in 10 seconds, and main bosses in maybe 20. Most rooms, even rooms with alot of tough enemies were a joke with this; full room of the knights with Isaac's face on the back of them... cleared in 10 seconds. :P

Had any OP item combos?
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Blabagas Feb 1, 2013 @ 1:46pm 
All of the above except instead of homing bombs I had homing tears which actually worked with Dr. Fetus. And to top it of... remote detonator. I beat blue baby without taking a single hit. My next best item combo which is a lot easy to get is Mom's knife + Polyphemus.
ITACHI Feb 1, 2013 @ 3:37pm 
Ive had that run but whit the poison bombs aswell... it makes it even more powerfull
7. Feb 1, 2013 @ 4:44pm 
I wish that I could get some item combo like that; it seems that the game hates Samson and I can never get a good item combo with him :(
Krova Steel Feb 1, 2013 @ 6:36pm 
I Had Technology with Max rate, book of shadows and max damage. with vampire and full hearts it was pretty bad. but I suck so it was my first time beating the game when i got that.
TriforceCollector♐ Feb 1, 2013 @ 7:40pm 
Had the same run but with: Book of Revelations, Nuns Habit, Battery, Polaroid, Guppies Paw (All spirit hearts), and a bunch of familiars
TriforceCollector♐ Feb 1, 2013 @ 7:40pm 
Originally posted by cenho09:
I wish that I could get some item combo like that; it seems that the game hates Samson and I can never get a good item combo with him :(
Same here, Samson has the worst item luck ever, as in Lemon mishap EVERY run
[FEZ] Mr. G (Man) Feb 3, 2013 @ 4:47am 
All ya need is Book of Revelation and Nuns Habit for an easy rush through Chest!!
lobsterfaceb Feb 3, 2013 @ 3:06pm 
Wafer, Yum Heart, the Habit. With homing poison bombs.
Satan dropped like a rock.
Getting Epic Fetus in a run is also a guarenteed victory, but I didn't have it then.
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Date Posted: Feb 1, 2013 @ 12:08pm
Posts: 8