The Binding of Isaac

The Binding of Isaac

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jamesc70 Feb 1, 2013 @ 12:08pm
Most OP item combo ever - Homing Spectral Big Bomb shots lol
Dr. Fetus - all shots are bombs
Bobby Bomb - homing shots (homing bombs with the above)
Oujia board - all shots are spectral and pass through things like rocks
Mr. Mega - makes all bombs large bombs

Wow was that an easy runthrough, and first time I killed Sheol. Mini bosses went down in 10 seconds, and main bosses in maybe 20. Most rooms, even rooms with alot of tough enemies were a joke with this; full room of the knights with Isaac's face on the back of them... cleared in 10 seconds. :P

Had any OP item combos?
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Showing 1-8 of 8 comments
Blabagas Feb 1, 2013 @ 1:46pm 
All of the above except instead of homing bombs I had homing tears which actually worked with Dr. Fetus. And to top it of... remote detonator. I beat blue baby without taking a single hit. My next best item combo which is a lot easy to get is Mom's knife + Polyphemus.
ITACHI Feb 1, 2013 @ 3:37pm 
Ive had that run but whit the poison bombs aswell... it makes it even more powerfull
cenho09 Feb 1, 2013 @ 4:44pm 
I wish that I could get some item combo like that; it seems that the game hates Samson and I can never get a good item combo with him :(
Krova Steel Feb 1, 2013 @ 6:36pm 
I Had Technology with Max rate, book of shadows and max damage. with vampire and full hearts it was pretty bad. but I suck so it was my first time beating the game when i got that.
Had the same run but with: Book of Revelations, Nuns Habit, Battery, Polaroid, Guppies Paw (All spirit hearts), and a bunch of familiars
Originally posted by cenho09:
I wish that I could get some item combo like that; it seems that the game hates Samson and I can never get a good item combo with him :(
Same here, Samson has the worst item luck ever, as in Lemon mishap EVERY run
All ya need is Book of Revelation and Nuns Habit for an easy rush through Chest!!
MegaLobsterFace Feb 3, 2013 @ 3:06pm 
Wafer, Yum Heart, the Habit. With homing poison bombs.
Satan dropped like a rock.
Getting Epic Fetus in a run is also a guarenteed victory, but I didn't have it then.
Last edited by MegaLobsterFace; Feb 3, 2013 @ 3:08pm
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Date Posted: Feb 1, 2013 @ 12:08pm
Posts: 8