ehe Dec 17, 2012 @ 1:30pm
Most overpowered combination on paper
I am not talking about infinite health, or unlimited item charge with certain items. I am talking about what is your fantasy build in that game which you always want to play like. For example, my combination: Sacred Heart + Polyphemus + Max's Head + Choclate Milk + Mutant Spider. Just imagine, you will shoot 4 giant ( I guess every tear should aproximetly be as twice big as you ) tears that will kill pretty much everything they touch. What is your fantasy build?
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The 21 Sacraments Dec 18, 2012 @ 2:46am 
Sacred Heart + Mutant Spider + Parasite + extra range. In theory, the tears should, hit, split, and home back on the enemy.
Taiju Dec 18, 2012 @ 3:45am 
I've already had my best run ever. Ipecac and Homing tears. Was RIDICULOUSLY overpowered. I would like to see that + Max's Head + Polyphemous + Mutant Spider though.
potatoatak Dec 18, 2012 @ 8:07am 
My last playthrough wasnt mega OP but it was still pretty word, had mutant spider + spirit of the night + meat cube lvl 2, so essentially shot 5 spectral shots and could hide on rocks and not get hit :P
[GWJ] FSeven Dec 18, 2012 @ 6:26pm 
Technology 2.0 + Polyphemous was ridiculous. Fastest run I've ever had.

BadEvilWrong Dec 19, 2012 @ 10:37pm 
Mutant spider, Sacred Heart, 8-ball/9-tails, Max's Head, Polyphemous, Common Cold, Parasite, Tough Love, Mom's Contact, piercing and spectral shots, max range.

Oh god, I just pictured that combo in my head. *shivers* Just having the first three is enough to melt faces.
#Cheese #Lost files #Download Dec 20, 2012 @ 6:17pm 
Broken Mirror, Coal, Ipecac, sacred heart.


It sucks because it returns, but hopefully the homing will overpower the return
AxillaInAJar Dec 21, 2012 @ 2:37am 
wat does sacred heart do agen i only got it once a while ago XD
AxillaInAJar Dec 21, 2012 @ 2:46am 
tech 2 the mark the pact various health increasing foods dead cat ouja bord and 2 meat cubes
AxillaInAJar Dec 21, 2012 @ 2:50am 
or maybe polyphemus+mutant spider+radioactive spider i think that makes ur shots slow enemies down+deamon wings+ouja bord+dead cat+the pact+the mark+breakfast+lunch+dinner+more foods for more health
Indochina Dec 23, 2012 @ 5:46am 
Originally posted by BadEvilWrong:
Mutant spider, Sacred Heart, 8-ball/9-tails, Max's Head, Polyphemous, Common Cold, Parasite, Tough Love, Mom's Contact, piercing and spectral shots, max range.

Oh god, I just pictured that combo in my head. *shivers* Just having the first three is enough to melt faces.

pretty much the ultimate combo you can ever have, remaining in a "normal tear" configuration (ie no brimstone or other tear modifier).one shot everything. just add max tears and it will be so powerful the game will crash trying to load every tear XD
8bit_pirate Dec 28, 2012 @ 8:27am 
Technology 2 + chocolate milk.

laser never stops firing and keeps getting stronger the longer you are in a room.
Dalino Dec 28, 2012 @ 6:21pm 
I think any combination of itens could be improved with the Guppy Combo. =]
ManeGunner6 May 4, 2013 @ 12:08pm 
Tech 2 + Polyphemus as Cain.
I NEVER get Tech 2 as Cain.
x-calibar May 9, 2013 @ 2:00am 
I played the game today for the first time... Beat it thanks to an AMAZING combination :
http://s16.postimg.org/wfl732z91/issacwin2ndtime.jpg

Wish I had a better screenshot, but I think I had the following items :
Technology 2, Spider Bite, Spirit of the Night, Brimstone, Cat-o-nine-tails, Polyphemus, Scapular (I think), Wooden Spoon, I might have had bucket of lard, and whatever that extra head thing was..., and something that poisons the enemy...

So, basically I had a constantly firing laser that instantly slows the enemy, and sometimes they get poisoned; I fly swiftly through the room, and one-shot almost every boss with the brimstone attack...

Also, had the detonator... xD
Ninbi May 9, 2013 @ 9:02am 
Tech 2, Mom's Contact, Common Cold, Pinky Eye, Tech 1, Number 1, Cancer, Pentagram, Steven, Polyphemus, Sacred Heart, Mulligan, Rage, Wafer and Spirit of the Night.
A good challenge run would to have one spirit heart as blue baby, these items and no more spirit hearts allowed. Ultimate glass cannon.
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Date Posted: Dec 17, 2012 @ 1:30pm
Posts: 15