The Binding of Isaac

The Binding of Isaac

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ColonelVONJAZZ May 12, 2014 @ 9:56am
Best synergies available?
What are the best/your favourite synergies on BoI?
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Showing 1-9 of 9 comments
Dr.Sleepwalker :3 May 12, 2014 @ 10:12am 
glass May 12, 2014 @ 10:31am 
ipecac + my reflection :D

i thnk best synergy will be knife poly? is there anything that does higher damage?

Tech/fetus/ipecac/brim/knife is cool and all. but they arn't as fun :P so i'll state my favourite tear combo that doen't really involve any carry items: my reflection+ coal + spoon bender
Rashurk May 12, 2014 @ 3:15pm 
book of revelation (or yum heart) + habit + wafer
xen_tech May 12, 2014 @ 5:38pm 
chocolate milk+brimstone
scoombag May 12, 2014 @ 9:10pm 
Mom's Knife and Polyphemus is the best synergy. 300% damage on your knife.
Bearly a Panda May 13, 2014 @ 2:57am 
good synergy for BoI, any dmg up and moms knike/brimstone for brimsnapping. Oh and ofc sacred heart added in for a perfect run.
Abbott May 13, 2014 @ 3:39am 
The best synergy has to be Polyphemus and Mom's Knife, plus whatever tear effects you snagged on the way (Common Cold, Spider Bite, Mom's Contacts, etc.)

My favorite synergy, however, is Polyphemus and Technology. Infinite range, powerful shots, and a giant laser beam to annihilate your opponents!
Grue May 13, 2014 @ 12:06pm 
brimstone+polyphemus=game over
Higher Mind May 13, 2014 @ 12:25pm 
I once had sooooo much Damage-up items, like the vaccine thing, Pentagram, Blood of the Martyr, Steven... I wonder why though.
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Date Posted: May 12, 2014 @ 9:56am
Posts: 9