The Binding of Isaac

The Binding of Isaac

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wakuboys May 9, 2014 @ 11:45am
Best Synergy?
I got Tech 2, Brimstone, polyphemus before depths, but the game decided to crash my computer (Which never happened before in 60+ hours of play) so that made me curious about whether there are better synergies out there. I doubt it, but I didn't even unlock Everything Is Terrible yet, so their may as well be.
Last edited by wakuboys; May 9, 2014 @ 11:59am
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Showing 1-8 of 8 comments
Rashurk May 9, 2014 @ 11:57am 
I think the best is mom's knife polyphemus cuz you don't get delay and you get 2 hit kill on everything or book of revelations (or yum heart), wafer and habit (you are practically inmortal)
wakuboys May 9, 2014 @ 11:58am 
Originally posted by DFSRashurk:
I think the best is mom's knife polyphemus cuz you don't get delay and you get 2 hit kill on everything or book of revelations (or yum heart), wafer and habit (you are practically inmortal)
Though what is the best item combination you ever got?
chibilibi May 9, 2014 @ 12:40pm 
Polyphemus + Skinny Odd Mushroom + Habit + Book of Shadows + Having like 12 red hearts that I Guppy's Paw'd away + Mutant Spider = best combo I ever got
Last edited by chibilibi; May 9, 2014 @ 12:40pm
Another Lee Pun May 9, 2014 @ 12:50pm 
Samson with Mom's Knife, Gamekid, And Habit is overkill.
Last edited by Another Lee Pun; May 9, 2014 @ 12:50pm
Best item combination I ever had was technology+poly+several tear ups, I had the book of revelations+habit so I was invincible to the womb where I only took half damage. Destroyed isaac and ??? in like 10 seconds
dang, nice.
The-Poison-Muse May 10, 2014 @ 1:12pm 
if you play as cain and get tech2 + chocolate milk just tap the fire key once and you have a infinatly fireing lazer that keeps increasing in damage

also if you get 3 doller bill and find polyphemus keep entering and exiting the room untill you get triple shot when you pick up pollyphems when you leave polyphemus won't give you the tears down because poly and triple shot use like the same algorithm type thing
Last edited by The-Poison-Muse; May 10, 2014 @ 1:18pm
Technology and Poly. I beat The Chest twice just with this combo
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Date Posted: May 9, 2014 @ 11:45am
Posts: 8