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I guess my next question is this: Do you ever quit a game early over getting terrible items from the first floors? I'm starting to strategize where I have to have a decent combination of items from rooms and boss battles before completing the basement or else I start over.
Take a look at the achievement list, you'll be killing Mom quite a bit.
Maybe learning how to use what I'm given is important. I originally dismissed Guppy's paw as being a terrible item until I discovered the combo with it plus 9 lives. The whole becoming Guppy thing was an accidental discovery. Now I'm wondering what other item combos give you something special like that.
I sometimes let my wife pick a character for me besides Cain (her Isaac doesn't have D6 yet), and I just play with whatever I get, I even make nonsense deal with the devil just to increase the difficulty and still finish flawlessly with whatever setup I end up with.
The game becomes pretty easy once you know the mechanics inside out.
On the very first floor, if you are not satisfied with the items that you get from the Item Room and/or from the boss, hold "r" for 3 seconds to quick-restart the game. There's no penalty to restarting.
And take it from a guy with over 1,000 hours of Isaac, there's no shame in restaring either.
Once you get Platinum God, you can play "challenge runs", or "random runs", or any kind of special rule runs you desire.